Denizen Pharmaceuticals manufactures a combination of Nimesulide and Paracetamol that helps relieve pain, treat severe fever, and reduce inflammation caused by rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis. Sometimes the dose can also be taken to relieve muscle pain, back pain, and toothache.
Composition
Nimesulide – 100 mg
Paracetamol – 325 mg
Medicinal Benefits of Nimesulide And Paracetamol Tablets
The combination of Nimesulide and paracetamol is used for short-term treatment, such as:-
- Relief from pain of headache, back pain, neck pain, throat pain, sprains, and strains.
- The tablet can also be taken for conditions like Osteoarthritis, Rheumatoid arthritis related pain.
- It also reduces body temperature and inflammatory conditions.
- Treats menstrual and pelvic pain.
How Do Nimesulide And Paracetamol Work?
Nimesulide, a non-steroidal anti-inflammatory drug( NSAID), blocks COX2 and reduces the generation of prostaglandin chemicals that cause pain, inflammation, and severe pain in the body.
Thereafter, Paracetamol acts as a pain reliever and fever reducer. It works on the brain and central nervous system, reducing the production of prostaglandins in the body. The tablet is known to reduce body temperature and reduce fever.
Why Are They Combined?
These two drugs are combined because together they provide faster relief to the body or affected area. Nimesulide works as an anti-inflammatory drug, and Paracetamol reduces fever in the body.
Dosage
The dosage is usually based on the patient’s history. One should take this medicine as prescribed by the doctor. The combination is contraindicated for children and is prescribed to an individual over a certain age.
The normal dosage for an adult is as follows:-
- 100 mg of nimesulide twice a day.
- 500mg to 1000mg every 4-6 hours.
This combination is usually prescribed for short-term and the patient should not use it for more than 15 days. For children, the medications are based on the weight and age of the child.
Side Effects
The side effects of the combination of nimesulide and paracetamol are usually mild, and these should fade away once the treatment is completed. They are:-
- Nausea
- Vomiting
- Diarrhea
- Dizziness
One must consult a doctor if the above conditions are not cured within a specific period of time.
Drug Warnings:-
The combination is not advised to be taken by:-
- Patients suffering from liver disease. This includes conditions like Fatty liver, hepatitis, etc.
- Pregnant and breastfeeding women should consult their doctor before starting this medication.
- Patients having allergies to pain relievers such as aspirin, ibuprofen, and naproxen should avoid taking this medicine.
- Those with liver and heart issues are also not advised and should consult their treating doctor before taking this combination.
Precautions For Nimesulide
- Do not combine the drug nimesulide with any other NSAIDS without any clinical advice.
- Should not be used for the long term.
- Patients with a serious history of kidney, liver, and heart disease should consult their doctor before taking it.
Precautions For Paracetamol
- The patient must check for this drug in other medications to avoid accidental overdose.
- Avoid exceeding the recommended value.
Storage
The medicine should be stored in a cool and dry space away from direct sunlight and heat. The temperature should be between 20 degree to 25 degree celsius. The medicine should be kept out of the reach and sight of individuals.
Dietary Instructions
The patient should take light and non-spicy food. The medications must be taken after meals with a full glass of water.
